Patients from 105+ countries have trusted us
Join hundreds of happy patients who choose the right treatment and care.
Get A Quote
Uterine Sarcoma
- Days In Hospital 3 days
- Outside Hospital Stay 30 days
- Success Rate %
Minimum Cost
$ 6000
Maximum Cost.
$ 10000
Overview of Uterine Sarcoma in India
Sarcomas of the uterus are one of the types of soft tissue sarcomas and originate in the uterus or womb. The majority of these tumors are found in the muscle of the uterus (the myometrium). In addition, several types of these tumor forms originate in the tissue that lines the uterus (the endometrium).
Uterine sarcoma has a greater frequency of growth and metastasis (spreading) than the other two main types of uterine cancer or endometrial cancer. They can also recur (return) after treatment in certain cases. When they do, there are some tumors that grow near other pelvic organs and lymph nodes in the pelvis (such as the vagina; bladder; rectum; ovaries; and fallopian tubes) and others that grow in more distant sites, such as the liver or lungs.
Uterine sarcoma makes up only 2-5% of all uterine cancer (2/10,000) and is most often found in women aged 50-70.
What Is Uterine Sarcoma?
Uterine sarcoma is a cancer of the uterus that develops in the myometrium or muscular layer of the uterus. Uterine sarcoma is a rare form of cancer, making up 2% to 5% of all uterine cancers.
Sarcomas are tumours (cancers) that develop in muscle, bone and connective tissues, and cancers that begin in epithelial cells (cells that line most organs) are carcinomas. Carcinomas represent the majority of uterine cancer cases and sarcomas make up a small percentage of uterine cancer cases.
Types of Uterine Sarcoma:
Uterine sarcoma actually comes in a few different forms.
Uterine Leiomyosarcoma
This is the most common type out there. It starts in the muscle layer of the uterus—the myometrium—and moves fast. Black women get uterine leiomyosarcoma about twice as often as white women, and most people are diagnosed around age 50.
Endometrial Stromal Sarcoma
These tumors show up in the lining of the uterus, right in the supporting tissue called the stroma. Low-grade versions usually grow slowly and often rely on hormones like estrogen or progesterone to keep growing. High-grade tumors act differently—they grow quickly and are tougher to manage.
Undifferentiated Sarcoma
This kind is pretty rare. The tumors can pop up in either the muscle or the lining of the uterus, and they tend to spread fast.
Adenosarcoma
Also uncommon, adenosarcomas don’t usually spread very quickly. They make up only about 5 percent of uterine sarcomas.
Generally, there are 4 different stages of Uterine Sarcoma:
Stage 1 – Cancer is only found in the uterus.
Stage 2 – Cancer has invaded other parts of the body or nearby organs such as the ovaries, fallopian tubes, etc.
Stage 3 – Cancer has spread to other parts of the abdomen from its point of origin in the uterus.
Stage 4 – Cancer has spread to distant parts of the body from its point of origin in the uterus or any organ in the abdominal cavity.
Procedure:
Uterine sarcomas are a less frequently diagnosed, aggressive variant of malignancy that originates from the muscular and connective tissues within the uterus. Compared to the more frequently diagnosed endometrial cancers, uterine sarcomas exhibit unique characteristics that can include rapid growth patterns as well as extrapelvic spread during the early stages of disease progression. Treatment regimens for uterine sarcomas tend to be highly individualised due to their rarity, requiring a comprehensive care model whereby gynecologic oncologists, medical oncologists, and radiation oncologists collaborate in designing patient-specific treatment plans.
Surgery: The Primary Treatment
Surgical Treatment for Uterine Sarcoma at the Early Stage
Surgery is the principal treatment for uterine sarcoma; surgery is performed most effectively when uterine sarcoma is diagnosed in its earliest stages.
Surgical procedures that are commonly used are:
Total hysterectomy - removal of the uterus
Bilateral salpingo-oophorectomy (BSO) - removal of both the ovaries and fallopian tubes
Lymph node dissection - removal of some nearby lymph nodes to determine the extent of cancer spread
The primary goal of surgical treatment of uterine sarcoma is to remove the tumor completely. This is the only treatment of uterine sarcoma if the cancer is restricted to the uterus; this is the only treatment required for uterine sarcoma if the cancer is limited to the uterus.
If the tumor has invaded beyond the uterus, the surgeon may perform debulking surgery in an effort to remove as much of the tumor as possible, therefore increasing the effectiveness of subsequent treatments.
Radiation Therapy
Radiation treatment uses high-energy radiation to kill cancer cells or stop their growth. It can usually be used after surgery (adjuvant therapy) to decrease the chances of recurrence.
Types of Radiation:
External Beam Radiation Therapy (EBRT): External radiation aimed at the pelvis
Brachytherapy: Internal radiation near the tumor's location
Radiation is especially effective in controlling the local disease, especially for people with high-risk characteristics (large tumors, incomplete removal).
Chemotherapy
Chemotherapy is a form of treatment that works on the entire body (systemic) and is most frequently prescribed when a malignancy has spread (metastatic) and has a high likelihood of returning (recurrence).
Common Chemotherapy Agents Include:
- Doxorubicin
- Ifosfamide
- Gemcitabine
- Docetaxel
These agents can be used separately or together, based on the type of uterine sarcoma: either leiomyosarcoma or endometrial stromal sarcoma.
Hormone Therapy
Hormonal Therapy has been shown to be effective with specific subtypes of Sarcomas known as Hormone-Sensitive, such as Low-grade Endometrial Stromal Sarcoma (ESS).
Examples of Hormonal Treatments include:
- Progestins (such as Medroxyprogesterone)
- Aromatase Inhibitors
- Gonadotropin-Releasing Hormone (GnRH) Analogs
All of these treatments will act as an Estrogen Blocker, or will reduce the amount of Estrogen present, and, as a result, slow the growth of cancer cells.
Targeted Therapy
Targeted therapies for treating cancers specifically target the molecules or pathways responsible for cancer cell growth, thus making the treatment more tailored to the individual. As such, targeted therapy is now being used for the management of uterine sarcoma.
Some examples of such targeted therapies include:
- Pazopanib (tyrosine kinase inhibitor)
- Trabectedin
Targeted therapies specifically target cancer cells compared to older chemotherapy medications, which might give you less of a chance to experience adverse reactions from the medication.
Immunotherapy
Immunotherapy helps the person's immune system recognise and destroy abnormal cells (for example, cancer).
It is an area of research for uterine sarcoma; however, some potential drugs, such as immune checkpoint inhibitors, have shown effectiveness in some situations.
Best Doctors in India
Cost of Uterine Sarcoma in India
Sarcomas of the uterus are rare tumours that arise from muscle and connective tissue (stroma) within the uterus. The most frequent presenting symptom associated with uterine sarcomas is bleeding from the vagina. The fee for the treatment of sarcoma of the uterus in India will cost between 6,000 and 8,000 USD or more, depending on the stage of the disease and the type of treatment provided.
Prices of Different Types of Uterine Sarcoma Treatment in India
|
Treatment Type |
Average Cost in India (USD) |
|
Surgery (Hysterectomy) |
$2,400 – $4,800 |
|
Radiation Therapy |
$1,800 – $3,600 |
|
Chemotherapy |
$1,200 – $3,600 |
|
Targeted Therapy |
$3,000 – $6,000 |
|
Hormone Therapy |
$950 – $2,400 |
|
Immunotherapy |
$3,600 – $7,200 |
Cost of Uterine Cancer Treatment in Major Cities of India
|
City |
Minimum Cost (USD) |
Maximum Cost (USD) |
|
Ahmedabad |
USD 5400 |
USD 7200 |
|
Amroha |
USD 4800 |
USD 6400 |
|
Bangalore |
USD 6000 |
USD 8000 |
|
Chennai |
USD 6000 |
USD 8000 |
|
Delhi |
USD 6000 |
USD 8000 |
|
Delhi Ncr |
USD 6000 |
USD 8000 |
|
Faridabad |
USD 6000 |
USD 8000 |
|
Ghaziabad |
USD 6000 |
USD 8000 |
|
Gurgaon |
USD 6000 |
USD 8000 |
|
Gurugram |
USD 6000 |
USD 8000 |
|
Hyderabad |
USD 6000 |
USD 8000 |
|
Kochi |
USD 6000 |
USD 8000 |
|
Kolkata |
USD 6000 |
USD 8000 |
|
Mohali |
USD 5400 |
USD 7200 |
|
Mumbai |
USD 6000 |
USD 8000 |
|
Noida |
USD 6000 |
USD 8000 |
|
Panjim |
USD 5400 |
USD 7200 |
|
Pune |
USD 5400 |
USD 7200 |
Top Hospitals in India
Indications of Uterine Sarcoma:
Symptoms associated with uterine sarcomas include:
- Vaginal bleeding that is abnormal
- Vaginal discharge that is abnormal
- Feeling as though you have a full abdomen
- A lump or mass in the pelvic area
- Pelvic pain
- Frequent urination (as well as constipation)
Many of the major symptoms of uterine sarcomas look like their counterparts in patients with uterine cancer and noncancerous tumors, like fibroids.
Risk Factors:
The following factors may lead to an increased likelihood of developing uterine sarcoma:
Genetics: The gene that results in retinoblastoma can also increase susceptibility to some forms of uterine sarcoma. There exists another hereditary form of cancer, called hereditary leiomyomatosis and renal cell cancer (HLRCC), which is associated with uterine sarcomas.
Radiation Therapy to the Pelvis: Sarcoma from radiation of the pelvis is unusual, but can occur between the years of 5–25 after receiving radiation therapy.
Tamoxifen: Tamoxifen treatment for breast cancer may slightly increase the chance of developing uterine sarcoma after long-term use.